Transient activated fibroblasts contribute to zebrafish heart regeneration
Authors
- J.P. Junker
- D. Panáková
Journal
- Nature Genetics
Citation
- Nat Genet 54 (8): 1076-1077
Abstract
In the zebrafish heart, several transient fibroblast types appear after injury. High-throughput lineage tracing revealed that injury-responsive fibroblasts are derived from two distinct lineage origins: the epicardium and the endocardium. Targeted cell-type-specific depletion showed that at least one fibroblast type has a critical role in heart regeneration.