Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis
Authors
- L. Solé-Boldo
- S. Haas
Journal
- Nature Genetics
Citation
- Nat Genet 55 (9): 1430-1431
Abstract
In this issue of Nature Genetics, Lara-Astiaso et al. systematically characterized the functional roles of several chromatin factors in hematopoiesis by combining functional CRISPR screens with single-cell transcriptomics and chromatin accessibility profiling, revealing lineage biases and relationships with important transcription factors.