Envelope glycoprotein trimers as HIV-1 vaccine immunogens
Authors
- Q.J. Sattentau
Journal
- Vaccines
Citation
- Vaccines 1 (4): 497-512
Abstract
The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.