© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Profile Team Research Publications News Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications October 04, 2023 / Nat Commun European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation A. Budu-Aggrey A. Kilanowski M.K. Sobczyk S.S. Shringarpure R. Mitchell K. Reis A. Reigo R. Mägi M. Nelis N. Tanaka B.M. Brumpton L.F. Thomas P. Sole-Navais C. Flatley A. Espuela-Ortiz E. Herrera-Luis J.V.T. Lominchar J. Bork-Jensen I. Marenholz A. Arnau-Soler A. Jeong K.A. Fawcett H. Baurecht E. Rodriguez A.C. Alves A. Kumar P.M. Sleiman X. Chang C. Medina-Gomez C. Hu C.J. Xu C. Qi S. El-Heis P. Titcombe E. Antoun J. Fadista C.A. Wang E. Thiering B. Wu S. Kress D.M. Kothalawala L. Kadalayil J. Duan H. Zhang S. Hadebe T. Hoffmann E. Jorgenson H. Choquet N. Risch P. Njølstad O.A. Andreassen S. Johansson C. Almqvist T. Gong V. Ullemar R. Karlsson P.K.E. Magnusson A. Szwajda E.G. Burchard J.P. Thyssen T. Hansen L.L. Kårhus T.M. Dantoft A.C.S.N. Jeanrenaud A. Ghauri A. Arnold G. Homuth S. Lau M.M. Nöthen N. Hübner M. Imboden A. Visconti M. Falchi V. Bataille P. Hysi N. Ballardini D.I. Boomsma J.J. Hottenga M. Müller-Nurasyid T.S. Ahluwalia J. Stokholm B. Chawes A.M.M. Schoos A. Esplugues M. Bustamante B. Raby S. Arshad C. German T. Esko L.A. Milani A. Metspalu C. Terao K. Abuabara M. Løset K. Hveem B. Jacobsson M. Pino-Yanes D.P. Strachan N. Grarup A. Linneberg Y. Lee N. Probst-Hensch S. Weidinger M.R. Jarvelin E. Melén H. Hakonarson A.D. Irvine D. Jarvis T. Nijsten L. Duijts J.M. Vonk G.H. Koppelmann K.M. Godfrey S.J. Barton B. Feenstra C.E. Pennell P.D. Sly P.G. Holt L.K. Williams H. Bisgaard K. Bønnelykke J. Curtin A. Simpson C. Murray T. Schikowski S. Bunyavanich S.T. Weiss J.W. Holloway J.L. Min S.J. Brown M. Standl L. Paternoster September 29, 2023 / Genome Biol Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing L. Cui B. Yang S. Xiao J. Gao A. Baud D. Graham M. McBride A. Dominiczak S. Schafer R.L. Aumatell C. Mont A.F. Teruel N. Hübner J. Flint R. Mott L. Huang September 01, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda March 21, 2023 / Blood Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development N. Mueller-Calleja K. Grunz T.S. Nguyen J. Posma D. Pedrosa M. Meineck A. Hollerbach J. Braun S. Muth H. Schild K. Saar N. Hübner S. Krishnaswamy J. Royce L. Teyton N.A. Lemmermann J. Weinmann-Menke K.J. Lackner W. Ruf March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton Pagination First page « First Previous page ‹‹ Page 1 Current page 2 Page 3 Page 4 … Next page ›› Last page Last » News Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity. Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. Press Release No. 30 June 21, 2019 Berlin Straight to the heart An international team of researchers are seeking to explore the heart at a depth that was previously impossible. They have now received a grant of nearly four million US dollars from the Chan Zuckerberg Initiative – as one of the 38 Seed Networks working on the Human Cell Atlas. MDC researcher Norbert Hübner is co-coordinator of the project. Press Release No. 25 May 30, 2019 Berlin Unknown mini-proteins in the heart A team led by Professor Norbert Hübner’s MDC research group has observed the human heart cells’ “protein factories” in action, examining the entire tissue for the very first time. In an article published in Cell, the group reveals their surprising discoveries and the possibilities they contain for the future treatment of heart disease. Press Release No. 17 April 26, 2019 Berlin Unlocking the secrets of heart cells A heart seems to be pure physics: valves open and close, blood flows, electrical impulses control the heartbeat. A German-British research team is now looking at it in a different way. It will break down the heart into its smallest components - the cells - and unlock their secrets. The project is now being funded with 2.5 million euros for three years. Press Release No. 9 April 13, 2018 Berlin Two MDC scientists receive ERC grants worth several million euros Basic researchers Gary Lewin and Norbert Hübner are investigating the anchoring of ion channels and micropeptides in heart muscle cells. Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease Acute ischemia (lack of blood flow) and sustained high blood pressure have grave consequences for... Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease One of the causes of heart failure is the formation of excess connective tissue. An international team of researchers has discovered a specific treatment approach involving the signaling molecule interleukin 11. Their findings have now been published in the journal Nature. Pagination First page « First Previous page ‹‹ Page 1 Current page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last » Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1) Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531
Publications October 04, 2023 / Nat Commun European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation A. Budu-Aggrey A. Kilanowski M.K. Sobczyk S.S. Shringarpure R. Mitchell K. Reis A. Reigo R. Mägi M. Nelis N. Tanaka B.M. Brumpton L.F. Thomas P. Sole-Navais C. Flatley A. Espuela-Ortiz E. Herrera-Luis J.V.T. Lominchar J. Bork-Jensen I. Marenholz A. Arnau-Soler A. Jeong K.A. Fawcett H. Baurecht E. Rodriguez A.C. Alves A. Kumar P.M. Sleiman X. Chang C. Medina-Gomez C. Hu C.J. Xu C. Qi S. El-Heis P. Titcombe E. Antoun J. Fadista C.A. Wang E. Thiering B. Wu S. Kress D.M. Kothalawala L. Kadalayil J. Duan H. Zhang S. Hadebe T. Hoffmann E. Jorgenson H. Choquet N. Risch P. Njølstad O.A. Andreassen S. Johansson C. Almqvist T. Gong V. Ullemar R. Karlsson P.K.E. Magnusson A. Szwajda E.G. Burchard J.P. Thyssen T. Hansen L.L. Kårhus T.M. Dantoft A.C.S.N. Jeanrenaud A. Ghauri A. Arnold G. Homuth S. Lau M.M. Nöthen N. Hübner M. Imboden A. Visconti M. Falchi V. Bataille P. Hysi N. Ballardini D.I. Boomsma J.J. Hottenga M. Müller-Nurasyid T.S. Ahluwalia J. Stokholm B. Chawes A.M.M. Schoos A. Esplugues M. Bustamante B. Raby S. Arshad C. German T. Esko L.A. Milani A. Metspalu C. Terao K. Abuabara M. Løset K. Hveem B. Jacobsson M. Pino-Yanes D.P. Strachan N. Grarup A. Linneberg Y. Lee N. Probst-Hensch S. Weidinger M.R. Jarvelin E. Melén H. Hakonarson A.D. Irvine D. Jarvis T. Nijsten L. Duijts J.M. Vonk G.H. Koppelmann K.M. Godfrey S.J. Barton B. Feenstra C.E. Pennell P.D. Sly P.G. Holt L.K. Williams H. Bisgaard K. Bønnelykke J. Curtin A. Simpson C. Murray T. Schikowski S. Bunyavanich S.T. Weiss J.W. Holloway J.L. Min S.J. Brown M. Standl L. Paternoster September 29, 2023 / Genome Biol Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing L. Cui B. Yang S. Xiao J. Gao A. Baud D. Graham M. McBride A. Dominiczak S. Schafer R.L. Aumatell C. Mont A.F. Teruel N. Hübner J. Flint R. Mott L. Huang September 01, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda March 21, 2023 / Blood Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development N. Mueller-Calleja K. Grunz T.S. Nguyen J. Posma D. Pedrosa M. Meineck A. Hollerbach J. Braun S. Muth H. Schild K. Saar N. Hübner S. Krishnaswamy J. Royce L. Teyton N.A. Lemmermann J. Weinmann-Menke K.J. Lackner W. Ruf March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton Pagination First page « First Previous page ‹‹ Page 1 Current page 2 Page 3 Page 4 … Next page ›› Last page Last »
October 04, 2023 / Nat Commun European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation A. Budu-Aggrey A. Kilanowski M.K. Sobczyk S.S. Shringarpure R. Mitchell K. Reis A. Reigo R. Mägi M. Nelis N. Tanaka B.M. Brumpton L.F. Thomas P. Sole-Navais C. Flatley A. Espuela-Ortiz E. Herrera-Luis J.V.T. Lominchar J. Bork-Jensen I. Marenholz A. Arnau-Soler A. Jeong K.A. Fawcett H. Baurecht E. Rodriguez A.C. Alves A. Kumar P.M. Sleiman X. Chang C. Medina-Gomez C. Hu C.J. Xu C. Qi S. El-Heis P. Titcombe E. Antoun J. Fadista C.A. Wang E. Thiering B. Wu S. Kress D.M. Kothalawala L. Kadalayil J. Duan H. Zhang S. Hadebe T. Hoffmann E. Jorgenson H. Choquet N. Risch P. Njølstad O.A. Andreassen S. Johansson C. Almqvist T. Gong V. Ullemar R. Karlsson P.K.E. Magnusson A. Szwajda E.G. Burchard J.P. Thyssen T. Hansen L.L. Kårhus T.M. Dantoft A.C.S.N. Jeanrenaud A. Ghauri A. Arnold G. Homuth S. Lau M.M. Nöthen N. Hübner M. Imboden A. Visconti M. Falchi V. Bataille P. Hysi N. Ballardini D.I. Boomsma J.J. Hottenga M. Müller-Nurasyid T.S. Ahluwalia J. Stokholm B. Chawes A.M.M. Schoos A. Esplugues M. Bustamante B. Raby S. Arshad C. German T. Esko L.A. Milani A. Metspalu C. Terao K. Abuabara M. Løset K. Hveem B. Jacobsson M. Pino-Yanes D.P. Strachan N. Grarup A. Linneberg Y. Lee N. Probst-Hensch S. Weidinger M.R. Jarvelin E. Melén H. Hakonarson A.D. Irvine D. Jarvis T. Nijsten L. Duijts J.M. Vonk G.H. Koppelmann K.M. Godfrey S.J. Barton B. Feenstra C.E. Pennell P.D. Sly P.G. Holt L.K. Williams H. Bisgaard K. Bønnelykke J. Curtin A. Simpson C. Murray T. Schikowski S. Bunyavanich S.T. Weiss J.W. Holloway J.L. Min S.J. Brown M. Standl L. Paternoster
September 29, 2023 / Genome Biol Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing L. Cui B. Yang S. Xiao J. Gao A. Baud D. Graham M. McBride A. Dominiczak S. Schafer R.L. Aumatell C. Mont A.F. Teruel N. Hübner J. Flint R. Mott L. Huang
September 01, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch
July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann
June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa
June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch
May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda
March 21, 2023 / Blood Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development N. Mueller-Calleja K. Grunz T.S. Nguyen J. Posma D. Pedrosa M. Meineck A. Hollerbach J. Braun S. Muth H. Schild K. Saar N. Hübner S. Krishnaswamy J. Royce L. Teyton N.A. Lemmermann J. Weinmann-Menke K.J. Lackner W. Ruf
March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner
February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton
News Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity. Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. Press Release No. 30 June 21, 2019 Berlin Straight to the heart An international team of researchers are seeking to explore the heart at a depth that was previously impossible. They have now received a grant of nearly four million US dollars from the Chan Zuckerberg Initiative – as one of the 38 Seed Networks working on the Human Cell Atlas. MDC researcher Norbert Hübner is co-coordinator of the project. Press Release No. 25 May 30, 2019 Berlin Unknown mini-proteins in the heart A team led by Professor Norbert Hübner’s MDC research group has observed the human heart cells’ “protein factories” in action, examining the entire tissue for the very first time. In an article published in Cell, the group reveals their surprising discoveries and the possibilities they contain for the future treatment of heart disease. Press Release No. 17 April 26, 2019 Berlin Unlocking the secrets of heart cells A heart seems to be pure physics: valves open and close, blood flows, electrical impulses control the heartbeat. A German-British research team is now looking at it in a different way. It will break down the heart into its smallest components - the cells - and unlock their secrets. The project is now being funded with 2.5 million euros for three years. Press Release No. 9 April 13, 2018 Berlin Two MDC scientists receive ERC grants worth several million euros Basic researchers Gary Lewin and Norbert Hübner are investigating the anchoring of ion channels and micropeptides in heart muscle cells. Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease Acute ischemia (lack of blood flow) and sustained high blood pressure have grave consequences for... Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease One of the causes of heart failure is the formation of excess connective tissue. An international team of researchers has discovered a specific treatment approach involving the signaling molecule interleukin 11. Their findings have now been published in the journal Nature. Pagination First page « First Previous page ‹‹ Page 1 Current page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last »
Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large.
Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative.
Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity.
Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells.
Press Release No. 30 June 21, 2019 Berlin Straight to the heart An international team of researchers are seeking to explore the heart at a depth that was previously impossible. They have now received a grant of nearly four million US dollars from the Chan Zuckerberg Initiative – as one of the 38 Seed Networks working on the Human Cell Atlas. MDC researcher Norbert Hübner is co-coordinator of the project.
Press Release No. 25 May 30, 2019 Berlin Unknown mini-proteins in the heart A team led by Professor Norbert Hübner’s MDC research group has observed the human heart cells’ “protein factories” in action, examining the entire tissue for the very first time. In an article published in Cell, the group reveals their surprising discoveries and the possibilities they contain for the future treatment of heart disease.
Press Release No. 17 April 26, 2019 Berlin Unlocking the secrets of heart cells A heart seems to be pure physics: valves open and close, blood flows, electrical impulses control the heartbeat. A German-British research team is now looking at it in a different way. It will break down the heart into its smallest components - the cells - and unlock their secrets. The project is now being funded with 2.5 million euros for three years.
Press Release No. 9 April 13, 2018 Berlin Two MDC scientists receive ERC grants worth several million euros Basic researchers Gary Lewin and Norbert Hübner are investigating the anchoring of ion channels and micropeptides in heart muscle cells.
Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease Acute ischemia (lack of blood flow) and sustained high blood pressure have grave consequences for...
Science November 13, 2017 By stimulating the excessive buildup of connective tissue, signaling molecule contributes to heart disease One of the causes of heart failure is the formation of excess connective tissue. An international team of researchers has discovered a specific treatment approach involving the signaling molecule interleukin 11. Their findings have now been published in the journal Nature.
Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1)